PMTCT & Malaria (closed)

Team members: 
Ingrid Inion; Eric Van Marck; Cris Verhofstede; Els Goetghebeur; Kishorchandra Mandaliya; Fabian Mwanyumba; Marleen Temmerman
Team members: 
Ingrid Inion; Eric Van Marck; Cris Verhofstede; Els Goetghebeur; Kishorchandra Mandaliya; Fabian Mwanyumba; Marleen Temmerman

OBJECTIVES

  • To determine the prevalence and correlates of placental malaria in HIV1 infected and non-infected women, the effect of placental malaria on viral shedding in the genital tract, and the impact of placental malaria on perinatal HIV1 transmission

METHODS

  • Placental histology was used for detection of malaria parasites

ACTIVITIES

  • Newborns were tested for HIV1-PCR at 1 day and 6 weeks after birth

RESULTS

  • Malaria parasites were found in 9.1 % (34/372) of the HIV1 infected mothers and in 4.3 % (12/277) of HIV1 non-infected women (p= 0.018). No association was found between placental malaria and maternal viral load, or genital tract HIV1-DNA and RNA. Placental malaria did not correlate with in utero (2.9 versus 5.6%, p=0.509) nor peripartal HIV1 transmission (11.5 versus 15.4%, p=0.602)
Undefined
Project categories: 
Geography: 
Funding agencies: 
Partners: 
ICRH, University of Ghent Obstetrics and ICRH, University of Ghent Pathology, University of Antwerp HIV Reference Laboratory, University of Ghent Applied Mathematics, University of GhentCoast Provincial General Hospital, Mombasa
Project status: 
Closed
Project status: 
Closed
Period: 
6/1/2001-31/8/2001
Period: 
6/1/2001-31/8/2001
Ends on: 
Thursday, November 29, 2012
Ends on: 
Saturday, January 6, 2001
Ends on: 
Saturday, January 6, 2001