Publications

OBJECTIVE: To determine the impact of HIV infection on acute morbidity and pelvic tumor control following external beam radiotherapy (EBRT) for cervical cancer.

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This paper reports on the duration of HIV counselling sessions and the contents and quality of these sessions in an antenatal care facility in Mombasa, Kenya. Implications of inadequate counselling for the effectiveness of PMTCT programmes are discussed.

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Invasive cervical cancer (ICC) is common in areas where human immunodeficiency virus (HIV) is also prevalent. Currently, HIV seroprevalence as well as acceptability of HIV testing in ICC patients in Kenya is unknown. The objective of this study was to determine the acceptability of HIV testing among patients with ICC. Women with histologically verified ICC at Kenyatta National Hospital participated in the study. A structured questionnaire was administered to patients who gave informed consent. HIV pre- and posttesting counseling was done.

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Quantification of the viral burden and identification of drug resistant mutations are important laboratory tools in the management of HIV-1 infected patients. However, widespread use of assays for viral load determination and genotyping is still hampered by the high cost. Here, an in-house RT-PCR-sequencing assay for HIV-1 drug resistance monitoring with the potential to be used both as a qualitative assay to detect the virus in plasma and as a genotyping system is described.

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Dr. Patricia Claeys defended her PhD thesis in October 2003, entitled: Cervical cancer screening in resource-poor settings, Evidence from Nicaragua and Kenya.

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Background: In sub-Saharan Africa, cervical cancer is the leading cancer among women. The causative role of different human papillomavirus (HPV) types in cervical cancer is established, but the distribution of HPV types within this region is largely unknown. Goal: The goal was to study the distribution of HPV among family planning clinic attendees in Nairobi, Kenya. Study Design: This was a cross-sectional study of persons attending a family planning center in Nairobi, Kenya.

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BACKGROUND: Data from sentinel serosurveillance are useful to estimate HIV infection in populations but may not be representative of the general population. General population-based surveys attempt to avoid selection bias and are the most appropriate for tracking changes in exposure to risk of HIV infection over time and assessing changes in behavior following prevention campaigns.

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